PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice
نویسندگان
چکیده
منابع مشابه
A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis*
Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in humans. Here we examined the effect of the I148M substitution on the enzymatic activity and cellu...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2019
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.30583